Curtius Rearrangement
Curtius Rearrangement Curtius Rearrangement Definition: The Curtius rearrangement is a rearrangement of acyl azides to give isocyanates, expelling the nitrogen gas. The isocyanates can then be used in the other…
Conversion to anhydrides [RCO2(–)]
Conversion to anhydrides [RCO2(–)] Conversion to anhydrides [RCO2‾] Definition: Addition of a carboxylic acid to an acid chloride results in the anhydride. Conversion to anhydrides [RCO2‾] Explained: Treatment of an acid chloride and a carboxylate…
Conversion to amides [RNH2]
Conversion to amides [RNH2] Conversion to amides [RNH2] Definition: Addition of primary and secondary amines (or ammonia) to acid chloride results in amides. Conversion to amides [RNH2] Explained: When treated with aqueous ammonia, primary and secondary amines convert acyl…
Conversion to aldehydes [LiAlH(OtBu)3]
Conversion to aldehydes [LiAlH(OtBu)3] Conversion to aldehydes [LiAlH(OtBu)3] Definition: Addition of the bulky reducing reagent lithium tri-t-butoxy aluminum hydride [LiAlH(OtBu)3] to acid chlorides results in the formation of aldehydes. Conversion to aldehydes [LiAlH(OtBu)3] Explained: Similar to…
Amide Formation from Acid Halides
Amide Formation from Acid Halides Amide Formation from Acid Halides Definition: Addition of primary and secondary amines (or ammonia) to acid chloride results in amides. Amide Formation from Acid Halides…