Reductive Amination

Reductive Amination Reductive Amination Definition: Aldehydes and ketones can be converted into amines, through the formation of an imine and treatment with a reducing agent. Reductive Amination Explained: Reductive amination is a method that converts aldehydes and ketones…

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Reactions of Diazonium Salts

Reactions of Diazonium Salts Reactions of Diazonium Salts Definition: Treatment of diazonium salts with various reagents leads to the formation of a new bond to the aromatic ring and loss of nitrogen (N2). Reactions of Diazonium Salts Explained: Aryldiazonium salts are…

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Hofmann rearrangement

Hofmann rearrangement Hofmann Rearrangement Definition: When amides are treated with halide and base, a rearrangement occurs, resulting in the loss of carbon dioxide and the formation of an amine. Hofmann rearrangement Explained: The Hofmann rearrangement is a special halogenation reaction…

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Grignard addition to aldehydes

Grignard addition to aldehydes Grignard addition to aldehydes Definition: Treatment of an aldehyde with Grignard reagent followed by water (acid) forms usually a secondary alcohol with a new carbon-carbon bond. This reaction is an addition reaction because the elements…

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Gabriel Synthesis of amines

Gabriel Synthesis of amines Gabriel Synthesis of Amines Definition: The Gabriel synthesis is a method for making primary amines through an SN2 reaction of a phthalimide with an alkyl halide followed by cleavage with hydrazine. Gabriel Synthesis of Amines…

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Formation of Diazonium Salts

Formation of Diazonium Salts Formation of Diazonium Salts Definition: Treatment of aromatic amines with sodium nitrite and HCl leads to the formation of diazonium salts. Formation of Diazonium Salts Explained:…

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Dehydration of amides to nitriles [P2O5]

Dehydration of amides to nitriles [P2O5] Dehydration of amides to nitriles [P2O5] Definition: Primary amides can be converted to nitriles with a dehydrating reagent such as P2O5. Dehydration of amides to nitriles [P2O5] Explained: Amides can be…

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Beckmann Rearrangement

Beckmann Rearrangement Beckmann Rearrangement Definition: The Beckmann rearrangement is a reaction of oximes that can result in either amides or nitriles, depending on the starting material. Beckmann Rearrangement Explained: The…

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Amide Formation Using DCC

Amide Formation Using DCC Amide Formation Using DCC Definition: Treatment of carboxylic acids with amines in the presence of the dehydrating agent N,N’-dicyclohexylcarbodiimide (DCC) leads to the formation of amides. This is particularly useful for peptide synthesis.…

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