Sharpless Epoxidation of alkenes

Sharpless Epoxidation of alkenes Sharpless Epoxidation of alkenes Definition: The Sharpless Epoxidation (or SAE, Sharpless Asymmetric Epoxidation) is an enantioselective epoxidation of allylic alcohols. Let’s remember, epoxidation is oxidation reaction of alkenes where cyclic…

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Epoxide opening [diol formation]

Epoxide opening [diol formation] Epoxide opening [diol formation] Definition: When aqueous acid is added to epoxide, trans-diol are formed. Epoxide opening [diol formation] Explained: When epoxides react with aqueous acids (often abbreviated H3O+) a three-membered…

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Epoxide opening [basic conditions]

Epoxide opening [basic conditions] Epoxide opening [basic conditions] Definition: When epoxides are treated with negatively charged nucleophiles, they will add to the least substituted position of epoxide in an SN2 reaction. Epoxides opening…

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Epoxide opening [acidic conditions]

Epoxide opening [acidic conditions] Epoxide opening [acidic conditions] Definition: When acid is added to epoxides, nucleophiles will add to the more substitution position. The stereochemistry of this addition is trans.…

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Epoxide formation [from halohydrins]

Epoxide formation [from halohydrins] Epoxides formation [from halohydrins] Definition: Halohydrins treated with strong base (such as hydroxide anion) can form epoxides through with intramolecular SN2 reaction. Epoxides formation [from halohydrins] Explained: When alkenes treated with…

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Epoxide formation [from alkenes]

Epoxide formation [from alkenes] Epoxide formation [from alkene] Definition: Epoxides or oxacyclopropanes can be obtained by reaction so-called epoxidation from alkenes with peroxy acids. Epoxide formation [from alkene] Explained: The most commonly…

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Epoxidation [RCO3H]

Epoxidation [RCO3H] Epoxidation Definition: Epoxidation is treatment where an electrophilic oxidizing agent is capable of introducing a single oxygen atom to connect to both carbons of a double bond. This…

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