{"id":9909,"date":"2024-04-19T00:17:24","date_gmt":"2024-04-19T00:17:24","guid":{"rendered":"https:\/\/chemistryscore.com\/?page_id=9909---0e2ee8c0-b117-423a-8d7f-56d6d6b9ecc0"},"modified":"2024-04-19T00:17:24","modified_gmt":"2024-04-19T00:17:24","slug":"reduction-ketones-nabh4","status":"publish","type":"post","link":"https:\/\/chemistryscore.com\/reduction-ketones-nabh4\/","title":{"rendered":"Reduction of ketones [NaBH4]"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"9909\" class=\"elementor elementor-9909\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8987719 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8987719\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e4f7da3\" data-id=\"e4f7da3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1eac6ee elementor-widget elementor-widget-text-editor\" data-id=\"1eac6ee\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h1>Reduction of ketones [NaBH4]<\/h1><h2>Reduction of ketones [NaBH<sub>4<\/sub>] Definition:<\/h2><p>Addition of\u00a0<strong>sodium borohydride<\/strong>\u00a0(NaBH<sub>4<\/sub>) to\u00a0<strong>ketones<\/strong>\u00a0gives\u00a0<strong>secondary alcohols<\/strong>\u00a0(after addition of\u00a0<strong>acid<\/strong>).<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-9911\" src=\"https:\/\/chemistryscore.com\/wp-content\/uploads\/2019\/11\/Reduction-of-ketones-NaBH41-1-768x286.png\" alt=\"\" width=\"768\" height=\"286\" srcset=\"https:\/\/chemistryscore.com\/wp-content\/uploads\/2019\/11\/Reduction-of-ketones-NaBH41-1-768x286.png 768w, https:\/\/chemistryscore.com\/wp-content\/uploads\/2019\/11\/Reduction-of-ketones-NaBH41-1-768x286-300x112.png 300w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><\/p><h2>Reduction of ketones [NaBH<sub>4<\/sub>] Explained:<\/h2><p><strong>Reduction<\/strong>, in organic chemistry, means the\u00a0<strong>addition\u00a0of hydrogen<\/strong>\u00a0to molecule or\u00a0<strong>removal of electronegative atoms<\/strong>\u00a0such as halogen or oxygen from the molecule.<\/p><p><strong>Hydride<\/strong>, by itself, is not a good nucleophile because it is not polarizable. But\u00a0<strong>sodium borohydride<\/strong>,\u00a0NaBH<sub>4\u00a0<\/sub>function as a delivery agent of nucleophilic\u00a0<strong>hydride anion<\/strong>. And the solvent function as the source\u00a0of a proton. The solvent can be ethanol, methanol, or water.<\/p><p>In this medium, the reagent donates hydride to the carbonyl carbon with simultaneous protonation of the carbonyl oxygen by the solvent. The intermediate which is obtained by first transferring of the hydride ion can attack three more carbonyl\u00a0substrates until all the hydride atoms of the original reagent have\u00a0been used up. Thus one equivalent of borohydride is capable of reducing four equivalents of a ketone to a secondary alcohol.<\/p><p><img decoding=\"async\" class=\"aligncenter size-full wp-image-9913\" src=\"https:\/\/chemistryscore.com\/wp-content\/uploads\/2019\/11\/Reduction-of-ketones-NaBH42-1-1024x259.png\" alt=\"\" width=\"1024\" height=\"259\" srcset=\"https:\/\/chemistryscore.com\/wp-content\/uploads\/2019\/11\/Reduction-of-ketones-NaBH42-1-1024x259.png 1024w, https:\/\/chemistryscore.com\/wp-content\/uploads\/2019\/11\/Reduction-of-ketones-NaBH42-1-1024x259-300x76.png 300w, https:\/\/chemistryscore.com\/wp-content\/uploads\/2019\/11\/Reduction-of-ketones-NaBH42-1-1024x259-768x194.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Reduction of ketones [NaBH4] Reduction of ketones [NaBH4] Definition: Addition of&nbsp;sodium borohydride&nbsp;(NaBH4) to&nbsp;ketones&nbsp;gives&nbsp;secondary alcohols&nbsp;(after addition of&nbsp;acid). Reduction of ketones [NaBH4] Explained: Reduction, in organic chemistry, means the&nbsp;addition&nbsp;of hydrogen&nbsp;to molecule or&nbsp;removal of electronegative atoms&nbsp;such as halogen or oxygen from the molecule. Hydride, by itself, is not a good nucleophile because it is not polarizable. But&nbsp;sodium borohydride,&nbsp;NaBH4&nbsp;function [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"on","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","_jetpack_memberships_contains_paid_content":false,"ocean_post_oembed":"","ocean_post_self_hosted_media":"","ocean_post_video_embed":"","ocean_link_format":"","ocean_link_format_target":"self","ocean_quote_format":"","ocean_quote_format_link":"post","ocean_gallery_link_images":"off","ocean_gallery_id":[],"footnotes":""},"categories":[5634],"tags":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v14.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reduction of ketones [NaBH4] - ChemistryScore<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chemistryscore.com\/reduction-ketones-nabh4\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reduction of ketones [NaBH4] - ChemistryScore\" \/>\n<meta property=\"og:description\" content=\"Reduction of ketones [NaBH4] Reduction of ketones [NaBH4] Definition: Addition of&nbsp;sodium borohydride&nbsp;(NaBH4) to&nbsp;ketones&nbsp;gives&nbsp;secondary alcohols&nbsp;(after addition of&nbsp;acid). Reduction of ketones [NaBH4] Explained: Reduction, in organic chemistry, means the&nbsp;addition&nbsp;of hydrogen&nbsp;to molecule or&nbsp;removal of electronegative atoms&nbsp;such as halogen or oxygen from the molecule. Hydride, by itself, is not a good nucleophile because it is not polarizable. 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