Addition of Gilman reagents to enones

Addition of Gilman reagents to enones Addition of Gilman reagents to enones Definition: Organocuprates (or Gilman reagents) will add to α,β-unsaturated ketones to give 1,4-addition products (or Michael addition products). Acid is added at the end of…

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Addition of Gilman to acyl halides

Addition of Gilman to acyl halides Addition of Gilman to acyl halides Definition: Addition of organocuprates (Gilman reagents) to acid chlorides results in ketones. Addition of Gilman to acyl halides…

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Acetylide addition [RC≡C(–)]

Acetylide addition [RC≡C(–)] Acetylide addition (RC≡C‾) Definition: Alkyl halides treated with acetylide anions will undergo  SN2 reactions to give alkynes. Acetylide addition (RC≡C‾) Explained: Acetylide anions are the conjugate base of acetylenes (alkynes), and this…

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