Oxidation to carboxylic acid [H2CrO4 or KMnO4]

Oxidation to carboxylic acid [H2CrO4 or KMnO4] Definition:

Chromium trioxide and water will oxidize aldehydes to carboxylic acids.

Oxidation to carboxylic acid [H2CrO4 or KMnO4] Explained:

The most common oxidation reaction of carbonyl compounds is the oxidation of aldehydes to carboxylic acids. As the oxidizing agents in these reactions, the following reagents can be used: CrO3, Na2Cr2O7, K2Cr2O7, and KMnO4Cr(VI) reagents are the most common used oxidation reagents. Ketones do not undergo this oxidation reaction because they have no hydrogen bonded to the carbonyl group.

Mechanism of Oxidation of Aldehydes with Chromic Acid [H2CrO4]

Chromic acid (H2CrO4) is mainly used to produce a carboxylic acid. It can be formed either from chromium trioxide (CrO3) or from sodium dichromate (Na2Cr2O7) in aqueous acidic solution.

Aldehydes that can form hydrates in the presence of water are further oxidized to carboxylic acids (B in the following reaction is base and it can be water or conjugate base of the acid):

Potassium permanganate, KMnO4, is a powerful oxidizing agent and has many uses in organic chemistry. It is able to oxidize carbon atoms if they contain sufficiently weak bonds, and the products that are obtained can vary depending on the conditions. At high temperature, ketones are cleavage oxidized by a strong oxidizing agent like KMnO4.

The most effective conditions for aldehyde oxidation by KMnO4 involve t-butanol as a solvent with a NaH2PO4 buffer.