Thioether formation RS-
Thioether formation (RS‾) Definition:
Thioether formation (RS‾) Explained:
Nucleophilic substitution at an sp³ hybridized carbon involves two σ bonds:
This process takes place simultaneously in one-step transformation.
In the transition state, both the leaving group and the nucleophile are partially bonded to the carbon which is sp² hybridized and the molecule is planar. As the reaction proceeds to products, the inversion motion is completed and the carbon returns to the tetrahedral sp³ configuration.