Epoxide opening [basic conditions]
Epoxide opening [basic conditions] Definition:
Epoxides opening [basic conditions] Explained:
Epoxides can be opened under acidic or basic conditions. When an epoxide is subject to attack by a strong nucleophile (such as hydroxide ion) in the first step, the ring opens in an SN2 process. This nucleophile attacks (back-side attack) an electron-deficient carbon of epoxide, thus cleaving the C-O bond. An alkoxide ion is obtained which then protonated by water in the next step to give the final product with two functional groups on adjacent atoms.