Stille Reaction Stille Reaction Definition: Stille reaction is a coupling reaction of an organotin (or organostannanes) with organohalide in the presence of a palladium catalyst. Stille Reaction Explained: Stille reaction is also a coupling reaction (like Heck and Suzuki reactions) which use…
SN2 with Gilman reagents SN2 with Gilman reagents Definition: Alkyl halides (or tosylates) will react with Gilman reagents (organocuprates) to form alkanes in SN2 reaction. SN2 with Gilman reagents Explained: A Gilman reagent is a lithium and diorganocopper reagent compound, R2CuLi (R = alkyl…
SN2 with alkyl halides SN2 with alkyl halides Definition: Nucleophilic bimolecular substitution (SN2) is the general reaction for primary and secondary haloalkanes (alkyl halides) where the halide functions act the leaving group, and…
SN1 Hydride Shift Rearrangement SN1 rearrangement [hydride shift] Definition: The 1,2-hydride shifts can occur during the reactions if an unstable carbocations is formed next to a tertiary carbon. SN1 Hydride Shift Explained: We have already…
SN1 w/ rearrangement [alkyl shift] SN1 w/rearrangement [alkyl shift] Definition: The 1,2-alkyl shift can occur during the substitution reactions if an unstable carbocation is formed adjacent to a quaternary carbon. SN1 rearrangement [alkyl shift] Explained:…
Side chain bromination Side chain bromination Definition: When treated with N-bromosuccinimide (NBS) and light (hν) alkyl group adjacent to aromatic groups will be converted to into alkyl bromides. Side chain bromination Explained: This reaction is analogous to allylic…
Sharpless Epoxidation of alkenes Sharpless Epoxidation of alkenes Definition: The Sharpless Epoxidation (or SAE, Sharpless Asymmetric Epoxidation) is an enantioselective epoxidation of allylic alcohols. Let’s remember, epoxidation is oxidation reaction of alkenes where cyclic…
Robinson annulation Robinson Annulation Definition: The Robinson Annulation is a method for forming the six-membered ring. It is a sequential combination of the Michael addition and the intramolecular aldol condensation. Robinson Annulation Explained: The Robinson annulation is a ring-forming…
Reductive Amination Reductive Amination Definition: Aldehydes and ketones can be converted into amines, through the formation of an imine and treatment with a reducing agent. Reductive Amination Explained: Reductive amination is a method that converts aldehydes and ketones…
Reduction of thioacetals to alkanes [Raney Ni] Reduction of Thioacetals to Alkanes [Raney Ni] Definition: Thioacetals can be desulfurized to give alkanes through the use of the Raney nickel (Ra-Ni). Reduction of Thioacetals to Alkanes…